When was the last time you looked at the driver's side door wiring harness? They are known to fail (badly) over time. The wires get brittle and break at the crimp. That harness connects to the alarm/lock control unit in the driver's door. It has 24 wires in it, so depending on which ones may be broken, you'll see a loss of certain services. Test other functions (mirrors, etc.), to see if it's more pervasive than just the locks. Might wiggle the harness in the door jamb and see if anything changes. When I picked up my well traveled CRV a few months ago with 179K mi, I had 6 broken wires in there once I took it apart. I would attach the schematic, but it exceeds the file size and the current computer I'm at can't shrink the file.